⚠️ NOT FOR HUMAN CONSUMPTION – FOR RESEARCH PURPOSES ONLY ⚠️ MOTS‑cA 16-amino-acid mitochondrial-derived peptide (Mitochondrial Open Reading Frame of the 12S rRNA‑c), encoded within mitochondrial DNA, that functions as a novel metabolic regulator. Form: Lyophilized powder Purity: >98% (HPLC) Storage: Store in a cool, dry, and dark environment—long-term storage typically at –20 °C(Source: PMC MotS‑c overview) Research Highlights Acts as a mitochondrial-to-nuclear signaling peptide: upon metabolic stress or exercise, MOTS‑c translocates to the nucleus and modulates gene expression—particularly those involved in energy balance and cellular resiliencePMCBioMed Central. Enhances glucose metabolism, improves insulin sensitivity, and prevents high-fat diet–induced weight gain and insulin resistance in animal modelsPubMedPMC. Functions through activation of the AMP-activated protein kinase (AMPK) pathway—regulating metabolic homeostasis, lipid oxidation, and cellular stress responsesBioMed CentralPubMed. In a diabetic rat model, administration of MOTS‑c improved cardiac mitochondrial function, reduced fasting glucose levels, and mitigated cardiac hypertrophy frontiers. Exercise elevates endogenous MOTS‑c levels: skeletal muscle expression increases dramatically (~12-fold), with modest increases observed in plasma; effects vary by population and metabolic statePMCNatureAging-US. This compound is strictly intended for laboratory research use only.It is not approved for human or veterinary use, not a dietary supplement, and must not be used to diagnose, treat, cure, or prevent any disease or condition. FOR LABORATORY USE ONLY. NOT FOR HUMAN CONSUMPTION.