⚠️ NOT FOR HUMAN CONSUMPTION – FOR RESEARCH PURPOSES ONLY ⚠️ PNC‑27A synthetic anti-cancer peptide composed of a p53-derived HDM-2 binding domain (residues 12–26 of p53) linked to a membrane-penetrating peptide (“penetratin”). Designed to target cancer cells by binding to HDM-2 expressed in their cell membranes and inducing selective transmembrane pore formation. Form: Lyophilized powder Purity: >98% (HPLC) Storage: Stable at room temperature for ~3 weeks when desiccated; long-term storage recommended at –20 °C. Upon reconstitution, store at 4°C for 2-7 days. Adding 0.1% HSA or BSA may improve stability—avoid freeze-thaw cycles.(Source: ProSpecBio product info – PNC‑27) prospecbio.com Research Highlights Selective membrane targeting: Binds to membrane-bound HDM-2 in cancer cells, forming transmembrane pores and causing necrotic cell death—while sparing normal cells.(Sources: Annals of Clinical Laboratory Science (2014) – leukemia model; Recent mechanism study (2024) – mitochondrial disruption) PubMed+1 Rapid cancer cell necrosis (“poptosis”): Induces explosive tumor cell death via membranolysis, independent of p53 activation.(Source: MDPI review on peptide-induced poptosis) MDPI Broad-spectrum antitumor activity: Demonstrated cytotoxicity in various cancer cell types—solid and hematologic—including pancreatic, breast, ovarian, cervical, leukemia, melanoma—while non-transformed cells remain unaffected.(Sources: Review on broad cancer targeting; Selectivity in cervical cancer models, 2025) Peptide SciencesEuropean Society of Medicine - Targeting design and origin: Engineered to mimic the p53 domain that binds HDM-2, conjugated with a leader sequence to facilitate membrane penetration and effectiveness.(Sources: Biomedicines review on PNC‑27 design; ProSpecBio design summary) MDPIprospecbio.com This compound is strictly intended for laboratory research use only.It is not approved for human or veterinary use, not a dietary supplement, and must not be used to diagnose, treat, cure, or prevent any disease or condition. FOR LABORATORY USE ONLY. NOT FOR HUMAN CONSUMPTION.